If you have someone to watch your kids, do it!!
We went to hawaii for our 10 year and like sara, I was much more worried about something happening to us and leaving our kids without parents. We had a fabulous time together and it's amazing what you can accomplish without kids.
We probably won't do a big trip like that again until the kids are old enough to be by themselves or much easier to take care of because they would be older, just because we have more kids and it would be a lot harder to find someone to stay with them for a long period of time. I do, however, fully intend to go somewhere close by for a couple nights every few years... once we're done having babies.
