I have an Acura MDX and would NOT recommend it for more than 2 car seat families. We have the third row seats in the back, but it is not really made for comfort. We have it so that when the kids have a friend or if my older stepsons were with us, we can fit 7.
My next vehicle will be a Honda Oddyssey(spelling?) or the Toyota Sienna. I held out getting a van for as long as I can, but we rented one on vacation and getting the kids and gear in and out of the car is soooo much easier with a van. My friend has a Toyota Sequoia and it fits a ton of people, no problem. I am short(4'11") and in a big car like that, I would defninatley be a danger to myself and others!