They're super huge if you don't.
It depends on how you store and what you do with your layouts.
In order to upload them to galleries, you should flatten the layout, size appropriately and save that copy for a webversion that can be deleted once you've uploaded it. If you print, you should also flatten it, make appropriate adjustments in size and sharpness, and save that until you've printed.
If you're talking about just storage of the layout, itself, I save the layered version until it's printed, then delete, but I always save a high resolution flattened version of the full-sized layout to store in case I need it in the future.
Is this what you meant?
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